Crystal structure of the catalytic core of an RNA-polymerase ribozyme
Published in Science, 2009
Recommended citation: DM Shechner, SC Bagby, R Grant, Y Koldobskaya, J Piccirilli, and DP Bartel (2009). "Crystal structure of the catalytic core of an RNA-polymerase ribozyme." Science 326:1271.
An RNA enzyme evolved from random sequence relies on familiar Mg2+-dependent chemistry to catalyze phosphodiester bond formation. X-ray crystallography, enzymology, structural biochemistry.