Crystal structure of the catalytic core of an RNA-polymerase ribozyme

Published in Science, 2009

Recommended citation: DM Shechner, SC Bagby, R Grant, Y Koldobskaya, J Piccirilli, and DP Bartel (2009). "Crystal structure of the catalytic core of an RNA-polymerase ribozyme." Science 326:1271.

An RNA enzyme evolved from random sequence relies on familiar Mg2+-dependent chemistry to catalyze phosphodiester bond formation. X-ray crystallography, enzymology, structural biochemistry.

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