Sarah C. Bagby

Sarah C. Bagby

Environmental microbiologist at Case Western Reserve University

Sitemap

A list of all the posts and pages found on the site. For you robots out there is an XML version available for digesting as well.

Pages

Posts

Blog Post number 4

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Blog Post number 3

less than 1 minute read

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Blog Post number 2

less than 1 minute read

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Blog Post number 1

less than 1 minute read

Published:

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portfolio

publications

Efficient phage-mediated pigment biosynthesis in oceanic cyanobacteria

Published in Current Biology, 2008

Auxiliary metabolic genes in cyanophage exploit a non-host-derived mechanism of pigment biosynthesis. Enzymology, metagenomics, qRT-PCR.

Recommended citation: TD Dammeyer, SC Bagby, MB Sullivan, SW Chisholm, and N Frankenbert-Dinkel. (2008). "Efficient phage-mediated pigment biosynthesis in oceanic cyanobacteria." Curr Biol 18(6):442.

Identification and structural analysis of a novel carboxysome shell protein with implications for metabolite transport

Published in Journal of Molecular Biology, 2009

A previously unrecognized component of bacterial microcompartments shows potential for dynamic gating. Bioinformatics, x-ray crystallography, expression analysis.

Recommended citation: M Klein, P Zwart, SC Bagby, F Cai, SW Chisholm, S Heinhorst, G Cannon, and CA Kerfeld (2009). "Identification and structural analysis of a novel carboxysome shell protein with implications for metabolite transport." J Mol Biol 392(2):319.

Crystal structure of the catalytic core of an RNA-polymerase ribozyme

Published in Science, 2009

An RNA enzyme evolved from random sequence relies on familiar Mg2+-dependent chemistry to catalyze phosphodiester bond formation. X-ray crystallography, enzymology, structural biochemistry.

Recommended citation: DM Shechner, SC Bagby, R Grant, Y Koldobskaya, J Piccirilli, and DP Bartel (2009). "Crystal structure of the catalytic core of an RNA-polymerase ribozyme." Science 326:1271.

A class I ligase ribozyme with reduced Mg2+ dependence: selection, sequence analysis, and tertiary-structure mapping

Published in RNA, 2009

A ribozyme selected for rapid catalysis shows changes to a network of structural interactions that contribute to metal-binding. In vitro evolution, statistics, structural biochemistry.

Recommended citation: SC Bagby,1 NH Bergman,1 DM Shechner, C Yen, and DP Bartel (2009). "A class I ligase ribozyme with reduced Mg2+ dependence: selection, sequence analysis, and tertiary-structure mapping." RNA 15:2129. (1joint first authors)

Asphalt volcanoes as a potential source of methane to late Pleistocene coastal waters

Published in Nature Geoscience, 2010

A newly discovered cluster of extinct asphalt volcanoes on the Santa Barbara Basin seafloor may explain historical methane anomalies. Submarine exploration, hydrocarbon geochemistry, paleoclimate.

Recommended citation: DL Valentine, CM Reddy, C Farwell, TM Hill, O Pizarro, DR Yoerger, R Camilli, RK Nelson, E Peacock, SC Bagby, BA Clark, CN Roman, and M Soloway. (2010). "Asphalt volcanoes as a potential source of methane to late Pleistocene coastal waters." Nature Geosci 3:345.

Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcεRI

Published in Nature Structural & Molecular Biology, 2011

Entropy drives the high-affinity receptor interaction underlying asthma and allergy. X-ray crystallography, surface plasmon resonance, thermodynamics.

Recommended citation: MD Holdom, AM Davies, JE Nettleship, SC Bagby, B Dhaliwal, E Girardi, J Hunt, HJ Gould, AJ Beavil, JM McDonnell, RJ Owens, and BJ Sutton (2011). "Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcεRI." Nature Struct Mol Biol 18:571.

Fallout plume of submerged oil from Deepwater Horizon

Published in Proceedings of the National Academy of Sciences, 2014

Spill response teams found, and then lost, a plume of oil that had been trapped ~1 km deep in the Gulf of Mexico. We found its 3200-km2 contamination footprint on the seafloor. Hydrocarbon geochemistry, statistics, GIS.

Recommended citation: DL Valentine, GB Fisher, SC Bagby, RK Nelson, CM Reddy, SP Sylva, and MA Woo (2014). "A fallout plume of submerged oil from Deepwater Horizon." PNAS 111:15906.

Targeted diversity generation by intraterrestrial archaea and archaeal viruses

Published in Nature Communications, 2015

A genomic cassette with more diversity-generating potential than the vertebrate immune system is active in archaea and archaeal viruses, not just in bacteria and bacteriophage. Metagenomics, single-cell genomics, evolution.

Recommended citation: BG Paul, SC Bagby, E Czornyj, D Arambula, S Handa, A Sczyrba, P Ghosh, JF Miller, and DL Valentine (2015). "Targeted diversity generation by intraterrestrial archaea and archaeal viruses." Nature Comm 6:6585. DOI: 10.1038/ncomms7585.

Response of Prochlorococcus to varying CO2:O2 ratios

Published in The ISME Journal, 2015

Minimal marine phototrophs use oxygen reduction as a safety valve when CO2 limitation makes ordinary light levels stressful. Growth curves, flow cytometry, transcriptomics.

Recommended citation: SC Bagby and SW Chisholm. (2015). "Response of Prochlorococcus to varying CO2:O2 ratios." ISME J 9(10):2232.

The Tao of open science for ecology

Published in Ecosphere, 2015

Ecologists need to change the way we do our work, to make open, reproducible research the norm. Opinion.

Recommended citation: SE Hampton, SS Anderson, SC Bagby, C Gries, X Han, EM Hart, MB Jones, WC Lenhardt, A MacDonald, WK Michener, J Mudge, A Pourmokhtarian, M Schildhauer, KH Woo, and N Zimmerman (2014). "The Tao of open science for ecology." Ecosphere 6:art120. DOI: 10.1890/ ES14-00402.1.

Persistence and biodegradation of oil at the ocean floor following Deepwater Horizon

Published in Proceedings of the National Academy of Sciences, 2016

A novel chemical fingerprint identifies sediment samples contaminated with oil from Deepwater Horizon, and the loss rates of 125 hydrocarbon analytes in these samples show that contamination level strongly influences chemical structure-based trends in biodegradation kinetics. Hydrocarbon geochemistry, statistics, more statistics.

Recommended citation: SC Bagby, CM Reddy, C Aeppli, GB Fisher, and DL Valentine. (2016). "Persistence and biodegradation of oil at the ocean floor following Deepwater Horizon." PNAS 114(1):E9. DOI: 10.1073/pnas.1610110114.

Methane-oxidizing bacteria shunt carbon to microbial mats at a marine hydrocarbon seep

Published in Frontiers in Microbiology, 2017

Microbial mats from a shallow hydrocarbon seep field are among the most diverse communities yet characterized, with multiple avenues of primary production. Stable isotope probing, metagenomics, lipid analysis.

Recommended citation: BG Paul, H Ding, SC Bagby, MY Kellermann, MC Redmond, GL Andersen, and DL Valentine. (2017). "Methane-oxidizing bacteria shunt carbon to microbial mats at a marine hydrocarbon seep." Front Microbiol 8:186. DOI: 10.3389/fmicb.2017.00186.

talks

Talk 1 on Relevant Topic in Your Field

Published in UC San Francisco, Department of Testing, 2012

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teaching

Teaching experience 2

Published in University 1, Department, 2015

This is a description of a teaching experience. You can use markdown like any other post.